Polynucleotides support deep skin regeneration by activating your body’s natural repair process—improving texture, tone, and elasticity with minimal downtime.
REVEAL NATURALLY RADIANT SKIN WITH POLYNUCLEOTIDES
Polynucleotide treatments use highly purified salmon DNA to stimulate the skin’s natural repair processes, boost hydration, and improve elasticity. Working on a cellular level, they support long-term skin health—making them ideal for those seeking natural, subtle rejuvenation without added volume.
BENEFITS OF POLYNUCLEOTIDE TREATMENT
Polynucleotides rejuvenate the skin by working on a cellular level. Unlike fillers or toxins, this treatment focuses on long-term skin health and repair—making it ideal for anyone looking for natural, subtle rejuvenation.
Clients typically experience:
- Firmer, more elastic skin
- Improved hydration and glow
- Smoothing of fine lines and crepey texture
- Reduction in dark circles and puffiness
- Accelerated skin healing and reduced inflammation
- Better skin quality on the face, neck, and under-eye area
- Long-lasting results with continued improvement after each session
MESO OX PDRN – ADVANCED REGENERATION FORMULA
Meso Ox PDRN is a powerful skin-rejuvenating solution designed to restore radiance, improve texture, and deeply hydrate the skin. This innovative cocktail combines three clinically proven ingredients that work in synergy to support long-term skin health—particularly in delicate or hard-to-treat areas.
25mg of PDRN
A DNA-based molecule derived from salmon that stimulates tissue regeneration, collagen production, and skin repair at a cellular level.
25mg of Niacinamide
Known for its brightening and anti-inflammatory properties, niacinamide helps reduce pigmentation, calm irritation, and strengthen the skin barrier.
36mg/ml of Hyaluronic Acid
A deeply hydrating ingredient included in three molecular weights to ensure immediate moisture retention, skin plumping, and long-lasting hydration across all layers of the skin.
This blend is carefully formulated to work synergistically, boosting the skin’s ability to regenerate and rejuvenate—naturally and effectively. Clients often report visibly brighter, smoother, and more hydrated skin after just a few sessions.
WHY CHOOSE ASTELAS FOR POLYNUCLEOTIDE TREATMENT
At Astelas, your skin’s health and safety come first. We are fully certified and regulated to perform polynucleotide treatments, using only medical-grade products for clinically proven results. With over 10 years of experience in the beauty and health industry, we combine expert knowledge with a personalised, honest approach. Every treatment is carried out with precision, care, and a commitment to helping you achieve natural, long-lasting skin rejuvenation.
ADVANCED TECHNIQUES & PREMIUM FORMULATIONS
At Astelas, we use only medical-grade polynucleotides derived from purified salmon DNA to ensure each treatment is both safe and effective. These high-quality formulations are carefully selected for their ability to stimulate natural skin regeneration, improve hydration, and support long-term skin health. We assess every treatment in detail before offering it in our clinic, ensuring it meets our standards for safety, science, and visible results. This allows us to deliver natural, long-lasting improvements without compromising on quality or care.
qualified MediCal Team
All polynucleotide treatments at Astelas are carried out by fully qualified, medically trained professionals with specialist experience in aesthetic and regenerative skin procedures. Our team combines clinical expertise with a deep understanding of facial anatomy to ensure every treatment is performed with precision and care. We are committed to ongoing training and professional development, staying up to date with the latest innovations in the field to provide our clients with safe, effective, and natural-looking results they can trust. Your comfort, confidence, and skin health are always at the centre of everything we do.
Treatment Details
During your polynucleotide treatment, you may feel a light pressure or mild pinching sensation as the product is gently injected into the skin. Slight redness, swelling, or sensitivity in the treated area is completely normal and usually settles within 24 to 48 hours. To support optimal healing, we recommend avoiding direct sunlight, heat exposure, and vigorous exercise for 1 to 2 days after treatment.
Condition treated
Scarring, Ageing, Loose Skin, Fine Lines, Wrinkles, Skin Texture / Oily, Dehydration, Stretch Marks, Superficial laxity, Uneven skin tone, Crows feet
Procedure time
30 minutes
PRACTITIONER
Nurse
DOWNTIME
Minimal
TREATABLE AREAS
Eyes, Face, Neck, Nasolabial folds, Smile lines, Upper eyelid, Lower eyelid, Decolletage, Hands
PRICE
Polynucleotide PRICING
| 1 Session | 3 Sessions | 5 Sessions | |
| Face | £130 | £330 | £500 |
| Neck | £90 | £240 | £350 |
| Decolletage | £130 | £360 | £575 |
| Face & Neck | £180 | £500 | £800 |
| Face & Decolletage | £230 | £630 | £1,000 |
| Face, Neck & Decolletage | £320 | £850 | £1,200 |
| Hands | £90 | £240 | £400 |
Frequently Asked Questions
Is this like filler or Botox?
No, polynucleotides are completely different from both fillers and Botox. Fillers add volume to areas of the face, and Botox relaxes facial muscles to smooth expression lines. Polynucleotides work on a cellular level to improve skin health, elasticity, and hydration—without freezing movement or changing facial contours. The result is subtle, natural rejuvenation over time.
What areas can be treated with polynucleotides?
Polynucleotides are incredibly versatile and are especially well-suited for delicate areas that are difficult to treat with fillers. These include the under-eye area (to reduce dark circles and fine lines), the neck, and hands. They’re also used across the full face to improve tone, hydration, and elasticity. In some cases, they can be applied to treat stretch marks, acne scarring, or early signs of sagging. Because they support natural regeneration, they’re ideal for anyone seeking subtle but noticeable skin improvement.
Is the treatment painful?
Polynucleotide treatments are generally well tolerated and only mildly uncomfortable for most people. A topical numbing cream is applied before the procedure to minimise any discomfort. The product is then injected using a fine needle or cannula, depending on the area being treated. Some clients describe a slight pressure, mild stinging, or a prickling sensation during the injections, but this typically fades quickly. If you are concerned about sensitivity, we’ll adjust your treatment to ensure you feel as comfortable as possible.
How soon can I return to normal activities?
One of the key advantages of polynucleotide treatment is the minimal downtime. Most clients can return to their daily routine immediately after the procedure. You may experience some mild swelling, redness, or small bumps at the injection sites, which generally subside within 24 to 48 hours. It’s best to avoid applying makeup or using active skincare on the treated area during this time. We also advise avoiding excessive sun exposure, hot environments, or vigorous exercise for at least one to two days following treatment.
When will I start seeing results?
You may notice your skin looking more hydrated and refreshed within a week of your first session. However, polynucleotides work gradually, so the most visible improvements in firmness, elasticity, and skin tone typically appear after the second or third session. Because they stimulate your body’s own regenerative processes, full results develop over several weeks. Continued improvement can be seen even after your treatment course is complete, especially if supported with a healthy skincare routine.
How many treatments will I need for best results?
For optimal and long-lasting results, we usually recommend a course of 3 to 4 sessions, spaced 2 to 3 weeks apart. This gives your skin time to rebuild its collagen and improve in tone, texture, and elasticity. After completing the initial course, we advise maintenance treatments every 6 to 9 months, depending on your skin’s needs and how it responds to the treatment. During your consultation, your practitioner will assess your goals and design a plan tailored specifically to you.
Can I combine polynucleotides with other skin treatments?
Yes, polynucleotides can be effectively combined with other aesthetic treatments for even better results. They work especially well alongside microneedling, skin boosters, and radiofrequency-based skin tightening, as these combinations enhance collagen production and improve skin tone and texture. Your practitioner will recommend the best treatment pairings based on your skin type, condition, and goals. Combining therapies can often deliver more dramatic improvements while still maintaining a natural look.
What should I avoid after the treatment?
To get the best possible outcome and avoid irritation, it’s important to take care of your skin after the treatment. For the first 24 to 48 hours, avoid direct sun exposure, hot showers, saunas, alcohol, and strenuous exercise. Don’t apply makeup or harsh skincare products, especially those containing acids or retinol, to the treated area during this period. Keeping your skin clean, hydrated, and protected will support healing and help maximise the treatment’s regenerative effects.
Who should avoid polynucleotide treatment?
While polynucleotide treatments are safe for most people, they are not suitable for everyone. We do not recommend them for clients who are pregnant, breastfeeding, allergic to fish or seafood, or who have certain autoimmune conditions or active skin infections. During your consultation, we will take a full medical history to assess your suitability and ensure the treatment is safe for you. Our priority is always to offer treatments that are appropriate, effective, and in your best interest.
